Society of African Journal Editors

African Journal of Traditional, Complementary and Alternative Medicines

Influence of Cardiospermum halicacabum leaf extract on membrane-bound ATPases in streptozotocin-induced diabetic rats

Authors: C Veeramani, KS Al-Numair, G Chandramohan, MA Alsaif, KV Pugalendi

Journal: African Journal of Traditional, Complementary and Alternative Medicines

Background : Cardiospermum halicacabum L. proved to have anti-inflammatory, antihyperglycemic, antioxidant, antiglycation, analgesic and antipyretic activities. It also has been used in Ayurveda and folk medicine for the treatment of rheumatism, fever and earache. Objective : The present study was aimed to evaluate the effect of Cardiospermum halicacabum leaf extract (CHE) on membrane-bound ATPases in streptozotocin (STZ)-induced diabetic rats. Methods : Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ (40 mg/kg BW). CHE (200 mg/kg BW) or glibenclamide (600 μg/kg BW) was administered orally once daily for 45 days to normal and STZ-induced diabetic rats. Results : The activities of membrane-bound ATPases such as total ATPase, Na + /K + -ATPase, Mg 2+ -ATPase and Ca 2+ -ATPase were significantly decreased in erythrocytes and tissues of STZ-induced diabetic rats. Oral administration of CHE to diabetic rats significantly increased the activities of these enzymes towards near normalcy. Conclusions : Thus, the present study indicates that the beneficial role of membrane-bound ATPases in STZ-induced diabetic rats. The antihyperglycemic, antioxidant and antihyperlipidemic properties of CHE could be helpful to maintain the activities of membrane-bound ATPases in STZ-induced diabetic rats showing the membrane stabilizing property of extract. Keywords : Streptozotocin, blood glucose, diabetes, membrane-bound ATPases, Cardiospermum halicacabum