The significant goal of this study is to develop a system to determine the margin of safety for ME3 super alloy in aerospace gas turbine engines. This margin of safety can be defined as critical temperature, force stress, exposure time, and cycles. In this research, by applying analytical solutions and using experimental data, equations are obtained to predict the life of a nickel-base super alloy in aerospace gas turbine engines. The experimental data that are applied to obtain the equations are achieved by gas turbine environment simulation experiments. This environment is contained with mechanical cycles at high temperature. The results that are achieved by these solutions are compared with the data from an experiment on a composite material. This comparison has proved that the results of this study seem logical. Ultimately, by employing of convex, concave, and linear equations, many results to predict the life of ME3 are obtained. Main reasons in ME3 failure at gas turbine engine environment is determined by this method. Based on the results of this research, the most important cause of ME3 failure is due to maximum mechanical force at high temperatures close to 763°C. Key words: Failure, nickel-base super alloy, gas turbine engines, mechanical fatigue, high temperature.